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oai:hiroshima.repo.nii.ac.jp:02006757 2025-02-21T08:20:48Z 1730444907710

Pathogenicity of nodavirus strains from striped jack Pseudocaranx dentex and Atlantic halibut Hippoglossus hippoglossus, studied by waterborne challenge of yolk-sac larvae of both teleost species. Totland, Geir K. Totland Geir K. Grotmo, Sindre Grotmo Sindre Morita, Yuseku Morita Yuseku Nishioka, Toyohiro Nishioka Toyohiro Nakai, Toshihiro Nakai Toshihiro open access Copyright (c) 1999 Inter-Research. Striped jack Atlantic halibut Fish nodavirus Pathogenicity Virulence Host specificity Immunohistochemistry 480 The present study shows that differences in pathogenicity exist among fish nodavirus strains. In challenge trials, a Japanese strain (SJ93Nag) was highly virulent to larvae of the striped jack Pseudocaranx dentex but replication was not detected in larvae of Atlantic halibut Hippoglossus hippoglossus at 6°C. Conversely, a Norwegian nodavirus strain (AH95NorA) that was highly virulent to the Atlantic halibut larvae did not replicate in striped jack larvae at 20°C. Occurrence of the disease viral encephalopathy and retinopathy (VER) and cumulative mortality were significantly different in the 2 species when challenged with the 2 nodavirus strains. The presence of nodavirus in nervous tissue was monitored by immunohistochemical methods. Our results support the view that the genetic diversity among nodavirus strains reflects the existence of different viral phenotypes which may be adapted to infect different host species and/or for replicating at different temperatures. Fish nodaviruses represent surveyable pathogens well suited for studying the relation between viral genotypic and phenotypic properties such as host specificity, temperature optima, neuroinvasiveness and neurovirulence. Inter-Research 1999-11-30 eng journal article VoR https://hiroshima.repo.nii.ac.jp/records/2006757 10.3354/dao038169 http://dx.doi.org/10.3354/dao038169 0177-5103 1616-1580 AA10443976 Diseases of Aquatic Organisms Diseases of Aquatic Organisms 38 3 167 167 175 https://hiroshima.repo.nii.ac.jp/record/2006757/files/dao038p169.pdf 676.5 KB